A primary purpose of the Senior Data Scientist - Structural Biology will be to leverage RF diffusion, protein modeling, and energy interaction analyses to optimize Nanobodies and design de novo binders targeting cancer.

The ideal candidate will have experience in structural biology and modeling of proteins

JOB SPECIFIC COMPETENCIES

AI modeling: design and optimize Nanobody binders using AI-based structural modeling (e.g., AlphaFold, RF diffusion) to evaluate antigen interactions. Apply computational approaches to predict energy landscapes and improve binder affinity/specificity.

Single cell analysis: integrate and analyze single-cell sequencing datasets (scRNA-seq, ATAC-seq, BCR-seq) to inform target biology and guide therapeutic design.

Leadership role in ongoing research projects: collaborate closely with experimental scientists to support ongoing preclinical and translational projects.

Other duties as assigned

EDUCATION:
Required: Bachelor's Degree Biomedical Engineering, Electrical Engineering, Computer Engineering, Physics, Applied Mathematics, Science, Engineering, Computer Science, Statistics, Computational Biology, or related field.
Preferred: Master's or Ph.D. degree in Structural Biology, Chemistry, or related field. .

EXPERIENCE:
Required: Five years experience in scientific software or industry programming with a concentration in scientific computing. With master's degree, three years of experience. With PhD, one year of experience.
Preferred: Experience structural biology and modeling of proteins.

The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition.

This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state, or local laws unless such distinction is required by law.http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Additional Information

Requisition ID: 177025
Employment Status: Full-Time
Employee Status: Regular
Work Week: Days
Minimum Salary: US Dollar (USD) 123,000
Midpoint Salary: US Dollar (USD) 154,000
Maximum Salary : US Dollar (USD) 185,000
FLSA: exempt and not eligible for overtime pay
Fund Type: Soft
Work Location: Onsite
Pivotal Position: Yes
Referral Bonus Available?: Yes
Relocation Assistance Available?: Yes

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